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A. baumannii lung infection model bioluminescent strain BV645

in vitro

  • Engineering and use of the same drug resistant clinical A. baumannii strain for in vitro and in vivo applications
  • Stable genomic bioluminescence label
  • Well characterized strains to better understand the infection models

High throughput in vivo model

  • Galleria mellonella infection model
  • Bioluminescence used for real-time analysis to better understand bacterial infections
  • Allows pre-screening of drug candidates
  • Model validation with Tigecycline

in vivo

  • Neutropenic lung infection model in mouse (Intranasal instillation)
  • Bioluminescence adds an additional real-time analysis layer to monitor bacterial infections
  • Model validation with Tigecycline

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